Treatment of Behcet's Disease

Profile of Behcet's Disease Specialized Department

Behcet's Disease (BD) Treatment Specialized Department, as one of the key departments of Yiling Hospital Affiliated to Hebei Medical University, has achieved distinct clinical therapeutic effects in the Treatment of Behcet's disease on the basis of sufficiently integrating the essence of traditional medicine with the advancing frontline achievements of modern medicine science as well as renovating concepts and innovating therapy on aspects of theory, experiment and clinical research. Now, the Treatment of Behcet's disease undertaken by the specialized department has been listed as a key science and technology project to be tackled by Hebei Provincial Science and Technology Department.

We sincerely hope that the establishment of the website will strengthen our communication and provide fundamental prevention and treatment knowledge of Behcet's disease; meanwhile, we wholeheartedly introduce our characteristic therapies against Behcet's disease, and provide consulting services on line at the same time so that you can get guidance from our experts while sitting at home.

Experts Introduction   Expert Consulting Service(for health every day)

Mr. Zhong Qicheng, Chief Physician and Professor

Mr. Zhong is the deputy director of the Treatment Center of Rheumatism and Immune Diseases. He was graduated from the Department of Traditional Chinese Medicine of Jiangxi College of Traditional Chinese Medicine, received further education in rheumatism and immunological diseases and has been engaged in clinical practices of TCM and Western medicine for almost 20 years. He has solid knowledge in the theories of TCM and Western medicine and rich clinical experience. He has profound scientific attainments in the treatment of lupus erythematosus, Behcet's disease, Sjogren syndrome, scleroderma, polymyositis, rheumatoid diseases, etc. The dredging therapy through local injection into the parotid gland for treatment of Sjogren syndrome is his original creation. The therapy is very unique and is with very remarkable therapeutic effects. Mr. Zhong has mastered the two sets of therapies, both the TCM series and the Western series, for the treatment of the above-mentioned diseases. He is very accomplished in taking the advantages of TCM to reduce and avoid the toxic and adverse reactions of Western medicines and reduce the risks of using Western medicines. Following the principle of diagnosing and treating diseases on the basis of an overall analysis of the illness and each patient 's conditions, he developed individualized therapies specific to different patients and different stages of the illness. So many cases of success have been achieved that they won him the hearty trust from the patients.

Mr. Zhong has been involved in the compiling of two academic books up to 800,000 Chinese characters in total. He published more than 30 technical papers on professional journals of national or provincial level, 2 academic books and 2 papers on international journals, which won him international prize of excellent papers. He has taken part in the research work in numerous research projects of national or provincial level and was selected as an Excellent Middle Aged TCM Doctor. Two of his achievements have been promoted in such areas as the Central China. His name has been listed in the "Chinese Scientists and Remarkable Experts Collection" and the "Dictionary of Famous Chinese Doctors". He is invited as the director of the China Association of Famous Doctors, the International Traditional Medicine Association of Canada, and the Hong Kong International Association of Traditional Medicine. He enjoys certain popularity both in and outside China.

Laser plus TCM Steaming and Washing Therapy for Various Ulcer Achieved Satisfactory Efficacy

Combined Internal and External TCM Therapy Benefited 3,000 Behcet's Disease Sufferers

Combined Internal and External TCM Therapy Benefited 3,000 Behcet's Disease Sufferers in Hebei Yiling Hospital

(News from our stuff reporter Wang Zhenling and correspondent Yang Sanping) It was known when gathering news in the teaching hospital--Hebei Yiling Hospital Affiliated to Hebei Medical University the other day, that a very unique therapy emphasizing both internal and external treatments as well as the advantageous characteristics of TCM has been developed in its Specialized Department of Behcet's Disease through concentrated research efforts of the chief physician, Mr. Zhong Qicheng and others. This intractable disease ever bothered both the doctors and the patients for long due to lack of satisfactory therapeutic methods. The new therapy has been applied to the treatment of more than 3,000 patients. The clinical results show that it has favorable therapeutic effects (the total effective rate up to 91.75%) and this brings new hope for the patients suffering from this disease.

Behcet's disease is a serious and complicated systemic disease that is prone to involve multiple systems and characterized by recurrent ulcers in the oral cavity, ulcers of the genitals, ophthalmic diseases as well as skin and vascular lesions. According to modern medical theories, the regular methods against this disease used to be expectant treatment, that is, to diminish the inflammation and relieve pain. Glucocorticoids and cytotoxins are often used to control this disease, but show unsatisfactory effects and rather significant adverse reactions. This often makes the patients hard to stick to the treatment, causing exacerbation of the disease and lesions in multiple organs and even death.

In order to develop a satisfactory therapeutic method against this disease, Mr. Zhong Qicheng, the chief physician in this hospital and et al worked out an innovative therapy emphasizing both internal and external treatments as well as the strength of TCM through a very unique concept based on his years' clinical experience and the thorough understanding of the pathogenesis according to the TCM theories. The so-called internal treatment is to categorize the patients firstly according to different disease stages and different symptoms of individual patients into Damp Heat and Toxin Exuberant Type, Yin Deficiency and Damp Heat Type, Qi Deficiency and Damp Heat Type, or Deficiency of Spleen & Kidney Type, and then select and use Baisailing Capsules No. 1 to 4 that are produced with modern hi-tech extraction methods to remove toxic heat, quench evil heat in the liver, remove dampness by diuresis, activate blood circulation, dissipate blood stasis, dissolve the stagnant, activate the channels and regulate the immune function of the patients so as to accelerate the curing of the ulcerous wound areas. The so-called external treatment is to use such external preparations as medicinal powder and creams for external application, which are developed with meticulous care, for treatment of newly appeared or stubborn ulcers in oral cavity or on the external genitalia and so on by means of external application, rinsing or ionic introduction, etc.

The modern pharmacological studies have shown that these preparations developed by them have the functions of removing toxic heat, activating blood circulation, dissipating blood stasis and so on, which can directly inhibit inflammations, accelerate absorption of inflammations, improve the generation of interferon in the body, ameliorate the platelet aggregation, clear away the immune complex on the endangium, promote vasodilatation, eliminate oedema of blood vessels, and restore the traumatic inner vascular walls.

――By Health News correspondent: Wang Zhenling from Hebei Medical University, Postcode: 050017

Combined Internal and External Therapy Benefited 3,000 Behcet's Disease Sufferers

Comprehensive Treatment of Behcet's disease with TCM Advantages

Behcet ’s disease is a serious and complicated systemic disease that is prone to involve multiple systems and is characterized by recurrent ulcers in the oral cavity, ulcers of the genitals, ophthalmic diseases as well as skin and vascular lesions. The modern medical research shows that this disease is associated with abnormal autoimmunity, hyperfunction of white cells and impairment of endothelial cells. The basic pathological change of Behcet 's disease is vasculitis, which leads to enhanced platelet agglutination, higher blood viscosity, sluggish blood flow and higher blood sedimentation rate. The interior diameters of blood vessels often turn smaller due to immune complex deposited on the basement membrane of cells, fibroplasia of inner wall membrane and vessel wall building up. On the acute stage, it appears exudative lesions, congestion of lumens, oedema of vessel walls and thrombogenesis due to endotheliocytic swelling in addition to exudation of neutrophilic granulocyte and red blood cells resulted from fibrinoid degeneration of vessel walls. Consequently, it forms vasculitis. In worse case, necrotizing angitis might occur as well due to immune complex deposited on the basement membranes of blood vessel cells extensively, which might get all blood vessels involved. In addition to lesions with oral cavity, eyes and genitals, it could also affect cardiovisceral vessels, lungs, digestive tract, nervous system, joints, kidneys, epididymis, etc.

According to modern medical theories, the regular methods against this disease is expectant treatment, that is, to diminish the inflammation and relieve pain. Glucocorticoids and cytotoxins are often used to control this disease, but show unsatisfactory effects and rather significant adverse reactions. This often makes the patients hard to stick to the treatment. Most medical workers are not fully aware the essence of this disease and patients often also pay insufficient attention to it on the early stage because of its refractoriness, recurrence and complexity. Even after the diagnosis is confirmed and medicines are prescribed, most patients can not persist with normal treatment for concerns of the toxic and side effects that may be brought about along with western medicine. As a result, the recurrence rate is very high and many patients fail to control the disease and inhibit the immune inflammation effectively, which leaves the disease aggravated, and some patients suffer from several internal organs impaired due to no treatment or improper treatment.

According to the pathological characteristics of this disease, we adopt TCM treatment based on differentiation of symptoms and signs and classification in several types. Four innovational methods are used mainly against this disease with favorable efficacy.

They include removing toxic heat, eliminating dampness and mucous discharge or quenching evil heat in the liver, promoting blood circulation to dispel blood stasis or dissolving the stagnant to activate the channels, and regulating the immunologic function to accelerate the curing of the ulcerous wound areas.

From the viewpoint of modern medical theory, the above-mentioned four methods are purposed to clear the deposited immune complex away from the basement membrane of blood vessel cells, fight against immune inflammation, enhance the permeability of the affected blood vessels, quicken the recovery of inflammatory cells, correcting the abnormal aggregation of platelets and fibroplasia caused by inflammation on the late stage so as to facilitate the balance of immunologic function.

The modern pharmacological studies have shown that heat-clearing and detoxifying drugs are able to inhibit inflammatory reaction directly, enhance the phagocytic function of reticuloendothelial system and improve the generation of interferon in the body; promoting blood circulation drugs are able to ameliorate the platelet aggregation, rectify viscous blood, accelerate blood flow, enhance the phagocytic function of oxyphils, soften the thick vessel wall, remove the immune complex buildup on endangium, expand blood vessel, promote the absorption of inflammation, eliminate the oedema of blood vessels, retard the fibrosis of vessel walls, restore traumatic inner walls of blood vessels, stabilize the internal environment of blood vessels, etc.

Therefore, it is concluded that the TCM therapy against Behcet 's disease based on classification and differentiation of symptoms and signs has achieved favorable efficacy, which can not only control the disease progress better, but also avoid those toxic and side effects coming along with western medicine.

Characteristic New Therapy Against Behcet's Disease

For many years, the treatment of Behcet's disease is always among the tough problems of immunologic diseases research in the global medical world. For the time being, there is no specific western medicine and therapy for it. Hormone, cytotoxic drugs and anti-inflammation/pain-killing drugs are mainly used clinically, which however can not control the progress of disease essentially, but relieve the disease temporarily. Plus, this method is not ideal in efficacy besides bad toxic and side effects. 

According to TCM theories, Behcet's disease is caused by evil factors such as damp heat and toxic factors that accumulate in the internal organs and affect mouth, eyes and external genitalia through channels and collaterals. Based on the belief that this disease is originated from the combined effects of dampness, toxicity and blood stasis, we created a therapeutic method--"balancing immunity for removal of ulcer" and established a unique theoretical system and medication principle against Behcet's disease. On that basis, a series of TCM preparations are developed that have such functions as regulating immunity, rectifying microcirculation, restoring ulcerous region, promoting the heal of ulcer, improving eyesight and rectifying chronic inflammation, of which the efficacy is proven by clinical practice.  

Treatment Guideline 1: Our center makes use of TCM as the major therapeutic measure, renovates the idea, innovates the therapies, and puts special emphasis on our advantages. Through long-term research, it is discovered that the major pathomechanism of Behcet's disease is combined effects of dampness, toxicity and blood stasis.  The key to treatment of this disease is to quench evil heat in the liver and remove dampness by diuresis, upon which a unique theoretical system and medication principle against Behcet's disease is formed, and Baisailing capsules and No.1-No.4 series of TCM preparations are developed. These preparations have such functions as regulating immunity, rectifying microcirculation, restoring ulcerous region, promoting the healing of ulcer, relieving chronic inflammation and other symptoms and signs. Clinical application indicates that these TCM preparations have favorable therapeutic effects for such as recurrent ulcerative stomatitis, other ulcerative stomatitis caused by Behcet's disease, genital ulcer, tunica uveae inflammation, dermal erythema nodosum, arthrodynia and other symptoms.

Treatment Guideline 2: Local application combined with systemic administration can enhance therapeutic effect. Behcet's disease is a type of systemic disease of which the major manifestation is local pathological changes. To effectively and rapidly release patients from subjective symptoms and physical signs such as ulcerative stomatitis and genital ulcer is what they expect. This purpose is achievable by applying such medicines as external application agent for ulcerous region, lotion and other preparations developed by our hospital, which can effectively release clinical symptoms in a short period. However, Behcet's disease is also a systemic disease accompanied with systemic immunological function disorder, so we must adjust the general immunologic function as a whole; therefore both local and systemic application of medicine is actually a treatment method concerning both secondary aspect and primary aspect of the disease.

Treatment Guideline 3: Emphasizing on early treatment to prevent further development of the disease and disease conditions involving multiple organs and systems. The manifestation of Behcet's disease in the early stage is mostly constantly attacked ulcerative stomatitis. These early manifestations are very easy to be overlooked during diagnosis and misdiagnoses may be resulted. If no enough attention is paid to this manifestation, the treatment may be postponed and the disease may be exacerbated and worsened. If diseases concerning multiple organs and systems are developed, the sufferings of the patients would be exacerbated, leading to cases that are relatively difficult to be cured and poor prognoses. So the aim of the clinical treatment includes the following two aspects, one is to treat the active disease and alleviate the clinical symptoms actively, and the other is to prevent the exacerbation of the disease, the possibility affecting multiple organs and multiple systems as well as any undesirable results.

For western medical theory currently, there is no specific western medicine and therapy for it. Hormone, cytotoxic drugs and anti-inflammation/pain-killing drugs are mainly used clinically, which however can not control the progress of disease essentially, but relieve the disease temporarily. Plus, this method is not ideal in efficacy along with bad toxic and side effects. According to TCM theories, Behcet's disease is caused by evil factors such as damp heat and toxic factors that accumulate in the internal organs and affect mouth, eyes and external genitalia through channels and collaterals. Based on the belief that this disease is originated from the combined effects of dampness, toxicity and blood stasis according to TCM theory, the latest achievements in scientific research and years' clinical experience, we created a therapeutic method--"removing heat from the liver and dampness by diuresis to cure ulcer" and established a unique theoretical system and medication principle against Behcet's disease. On that basis, Baisailing capsule and Baisailing No.1 to 4 series of pure TCM preparations are developed that have such functions as regulating immunity, rectifying microcirculation, restoring ulcerous region, promoting the heal of ulcer, improving eyesight and rectifying chronic inflammation as well as other symptoms and signs. Large amount of clinical experience indicates favorable efficacy and no evident toxic or side effect is detected, which brings new hope for the patients suffering from this disease.
  
Baisailing Capsule: 0.5×30 capsules/bottle/24RMB, 4-6 capsules/times, 3 times/day.
It is applicable to recurrent ulcerative stomatitis, other ulcerative stomatitis caused by Behcet's disease, genital ulcer and conjunctivitis.

Baisailing No. 1: 0.5×30 capsules/bottle/36RMB, 4-6 capsules/times, 3 times/day.
It is mainly applicable to recurrent ulcerative stomatitis and Behcet's disease patients who is classified as Damp Heat and Toxin Exuberant Type.
  
Baisailing No.2: 0.5×30 capsules/bottle/42RMB, 4-6 capsules/times, 3 times/day.
It is mainly applicable to recurrent ulcerative stomatitis and Behcet's disease patients who is classified as Yin Deficiency and Damp Heat Type.
 
Baisailing No.3: 0.5×30 capsules/bottle/24RMB, 4-6 capsules/times, 3 times/day.It is mainly applicable to recurrent ulcerative stomatitis and Behcet's disease patients who is classified as Qi Deficiency and Damp Heat Type.
  
Baisailing No.4: 6×12 pouches/bag/60RMB, 1 pouch/times, 2 times/day.
It is mainly applicable to recurrent ulcerative stomatitis and Behcet's disease patients who is classified as Deficiency of Spleen & Kidney Type.